Colorado Buffaloes upset No. 21 Arizona Wildcats in dramatic fashion

Buffaloes rally from 21-point deficit to win 34-30

Arizona's loss drops them to 2-2 on the season, while Colorado improves to 3-1

The Arizona Wildcats suffered a stunning 34-30 loss to the Colorado Buffaloes on Saturday night in Tucson. The Wildcats, who were ranked No. 21 in the AP Poll, led 21-0 in the second quarter but couldn't hold on.

The Buffaloes, who entered the game as 17-point underdogs, rallied behind quarterback JT Shrout. Shrout threw for 270 yards and two touchdowns, including the game-winning score to wide receiver Daniel Arias with just over two minutes remaining.

The Wildcats had a chance to tie the game on their final drive, but quarterback Jayden de Laura was intercepted by Colorado cornerback Mekhi Blackmon with just seconds remaining.

The loss drops Arizona to 2-2 on the season, while Colorado improves to 3-1. The Wildcats will look to rebound next week when they travel to California to face the Golden Bears.

Here are some of the key takeaways from the game:

• Colorado's defense played a huge role in the win. The Buffaloes held Arizona to just 30 points, including only 10 points in the second half. Colorado also forced three turnovers, including two interceptions of de Laura.
• JT Shrout had a breakout game for Colorado. The quarterback threw for 270 yards and two touchdowns, including the game-winning score. Shrout also ran for 54 yards, including a 20-yard touchdown run in the third quarter.
• Arizona's offense struggled in the second half. The Wildcats were held to just 10 points in the second half and were unable to sustain drives. Arizona also turned the ball over three times in the second half, including two interceptions of de Laura.
• The loss is a major setback for Arizona. The Wildcats were ranked No. 21 in the AP Poll and were hoping to make a run at the Pac-12 championship. The loss drops Arizona to 2-2 on the season and makes their path to the Pac-12 championship much more difficult.